An EEG source localisation study identified reliably the regions comprising the brain’s chronic pain matrix. The researchers detected significant overactivation of the Cingulate gyrus, the Insula, the parietal lobe, the thalamus, the S1 region and the dorsolateral prefrontal cortex (DLPFC) in a population of 77 chronic pain patients. These findings are consistent with the over-activation pattern reported in fMRI studies. Such consistency is of high clinical significance, as it confirms the capability of EEG and sLORETA to localise reliably neural activation.
The over activation of the pain matrix was observed in the Theta and Low Alpha frequency range suggesting thalamo-cortical disturbance associated with chronic pain. Here is the link to the abstract of this study in Clinical EEG and Neuroscience.