Genes Control Hyperactivity, while Gut Microbiome Mediates Social Behaviour

“Dr. Mauro Costa-Mattioli, professor and Cullen Foundation Endowed Chair in neuroscience and director of the Memory and Brain Research Center at Baylor, discovered with his team that different abnormal behaviors are interdependently regulated by the host’s genes and microbiome. Specifically, the team found that in mouse models for neurodevelopmental disorders, hyperactivity is controlled by the host’s genetics, whereas social behavior deficits are mediated by the gut microbiome.”

Source: Baylor College of Medicine. “Microbes may hold the key for treating neurological disorders.” ScienceDaily. ScienceDaily, 10 March 2021. <>.

Journal Reference:

  1. Shelly A. Buffington, Sean W. Dooling, Martina Sgritta, Cecilia Noecker, Oscar D. Murillo, Daniela F. Felice, Peter J. Turnbaugh, Mauro Costa-Mattioli. Dissecting the contribution of host genetics and the microbiome in complex behaviorsCell, 2021; DOI: 10.1016/j.cell.2021.02.009